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Article

A NANOS3 mutation linked to protein degradation causes premature ovarian insufficiency.

Cell death & disease - 3 Oct 2013

Wu X, Wang B, Dong Z, Zhou S, Liu Z, Shi G, Cao Y, Xu Y

Abstract excerpt

Primary ovarian insufficiency (POI), or premature ovarian failure, is defined as the cessation of ovarian function before the age of 40. An insufficient ovarian follicle pool derived from primordial germ cells (PGCs) is an important cause of POI. Although the Nanos gene family is known to be required for PGC development and maintenance in diverse model organisms, the relevance of this information to human biology...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24091668
DOI: 10.1038/cddis.2013.368
PMCID: PMC3824677

Genes

NANOS3
NANOS1
NANOS2
PGC

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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