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Article

Premature ovarian failure in mice with oocytes lacking core 1-derived O-glycans and complex N-glycans.

Endocrinology - 1 Mar 2011

Williams Suzannah A, Stanley Pamela

Abstract excerpt

Premature ovarian failure (POF) affects up to 1.4% of women under the age of 40 yr and less than 30% of cases have a known cause. Here we describe a new mouse model of POF resulting from oocyte-specific ablation of core 1-derived (mucin) O-glycans and complex and hybrid N-glycans. Females carrying floxed alleles of both the C1galt1 (T-syn) and Mgat1 glycosyltransferase genes and a ZP3Cre transgene, generate...

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Identifiers

PMID: 21239444
DOI: 10.1210/en.2010-0917
PMCID: PMC3040049

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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