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Article

Sequence variation at the human FOXO3 locus: a study of premature ovarian failure and primary amenorrhea.

Human reproduction (Oxford, England) - 1 Jan 2008

Gallardo Teresa D, John George B, Bradshaw Karen, Welt Corrine, Reijo-Pera Renee, Vogt Peter H, Touraine Philippe, Bione Silvia, Toniolo Daniela, Nelson Lawrence M, Zinn Andrew R, Castrillon Diego H

Abstract excerpt

BACKGROUND: The forkhead transcription factor Foxo3 is a master regulator and potent suppressor of primordial follicle activation. Loss of Foxo3 function in the mouse leads to premature ovarian failure (POF) due to global follicle activation. METHODS AND RESULTS: Here, we show that the mouse Foxo...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17959613
DOI: 10.1093/humrep/dem255
PMCID: PMC2579771

Genes

FOXO3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17959613-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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