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Article

Novel Loss-of-function Variants of ZP3 Associated with Premature Ovarian Insufficiency.

Reproductive sciences (Thousand Oaks, Calif.) - 1 Dec 2024

Zhou Lang, Yang Xi, Ren Shuting, Pan Yuncheng, Zhou Zixue, Liu Yiqing, Mo Jitong, Zhang Feng, Zhang Xiaojin, Wu Yanhua

Abstract excerpt

Premature ovarian insufficiency (POI) is one of the leading causes of female infertility. To date, the genetic etiology of POI has been elucidated in approximately 20-25% of the total cases. The human zona pellucida (ZP) plays an important role in the organization and differentiation of granulosa cells, follicle formation, and sperm recognition. Mutations in ZP1, ZP2, and ZP3 have been reported to cause female...

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Source

Identifiers

PMID: 39485610
DOI: 10.1007/s43032-024-01732-3

Genes

ZP3
ZP1
ZP2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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Novel Loss-of-function Variants of ZP3 Associated with Premature Ovarian Insufficiency.PMID 39485610Read ↗

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A novel mutation in ZP3 causes empty follicle syndrome and abnormal zona pellucida formation.Semantic proximity Read ↗

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Novel mutations in ZP1 and ZP2 cause primary infertility due to empty follicle syndrome and abnormal zona pellucida.Semantic proximity Read ↗

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Mutations in ZP4 are associated with abnormal zona pellucida and female infertility.Semantic proximity Read ↗

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