Article
The G <sub>s</sub> -Linked Receptor GPR3 Maintains Meiotic Arrest in Mammalian Oocytes
10 Dec 2004
Abstract excerpt
Mammalian oocytes are held in prophase arrest by an unknown signal from the surrounding somatic cells. Here we show that the orphan Gs-linked receptor GPR3, which is localized in the oocyte, maintains this arrest. Oocytes from Gpr3 knockout mice resume meiosis within antral follicles, independently of an increase in luteinizing hormone, and this phenotype can be reversed by injection of Gpr3 RNA into the oocytes....
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