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Article

Impaired T-cell priming in vivo resulting from dysfunction of WASp-deficient dendritic cells

2 Aug 2007

Abstract excerpt

The Wiskott-Aldrich syndrome (WAS) is characterized by defective cytoskeletal dynamics affecting multiple immune cell lineages, and leading to immunodeficiency and autoimmunity. The contribution of dendritic cell (DC) dysfunction to the immune dysregulation has not been defined, although both immature and mature WAS knockout (KO) DCs exhibit significant abnormalities of chemotaxis and migration. To exclude...

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PMID: 17673604
DOI: 10.1182/blood-2007-06-096875

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