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Article

General, negative feedback mechanism for regulation of Trithorax-like gene expression in vivo: new roles for GAGA factor in flies.

Nucleic acids research - 1 Jan 2007

Bernués Jordi, Piñeyro David, Kosoy Ana

Abstract excerpt

Expression of every gene is first regulated at the transcriptional level. While some genes show acute and discrete periods of expression others show a rather steady expression level throughout development. An example of the latter is Trithorax-like (Trl) a member of the Trithorax group that encodes GAGA factor in Drosophila. Among other functions, GAGA factor has been described to stimulate transcription of...

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Identifiers

PMID: 17947335
DOI: 10.1093/nar/gkm590
PMCID: PMC2175371

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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General, negative feedback mechanism for regulation of Trithorax-like gene expression in vivo: new roles for GAGA factor in flies.PMID 17947335Read ↗

Function of the Trithorax-like gene during Drosophila development.Semantic proximity Read ↗

The GAGA factor is required in the early Drosophila embryo not only for transcriptional regulation but also for nuclear division.Semantic proximity Read ↗

GAGA factor isoforms have distinct but overlapping functions in vivo.Semantic proximity Read ↗

The Trithorax-like gene encodes the Drosophila GAGA factor.Semantic proximity Read ↗

The Drosophila GAGA factor is required for dosage compensation in males and for the formation of the male-specific-lethal complex chromatin entry site at 12DE.Semantic proximity Read ↗

GAGA mediates the enhancer blocking activity of the eve promoter in the Drosophila embryo.Semantic proximity Read ↗

Drosophila FACT contributes to Hox gene expression through physical and functional interactions with GAGA factor.Semantic proximity Read ↗

A heat-shock-activated cDNA encoding GAGA factor rescues some lethal mutations in the Drosophila melanogaster Trithorax-like gene.Semantic proximity Read ↗

A homeotic mutation in the trithorax SET domain impedes histone binding.Semantic proximity Read ↗

The GAGA protein is essential for dorsal appendage formation during Drosophila melanogaster oogenesis.Semantic proximity Read ↗

Trithorax regulates multiple homeotic genes in the bithorax and Antennapedia complexes and exerts different tissue-specific, parasegment-specific and promoter-specific effects on each.Semantic proximity Read ↗

An interactive network of long non-coding RNAs facilitates the Drosophila sex determination decision.Semantic proximity Read ↗

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