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Article

Drosophila FACT contributes to Hox gene expression through physical and functional interactions with GAGA factor.

Genes & development - 1 Jul 2003

Shimojima Tsukasa, Okada Masahiro, Nakayama Takahiro, Ueda Hitoshi, Okawa Katsuya, Iwamatsu Akihiro, Handa Hiroshi, Hirose Susumu

Abstract excerpt

Chromatin structure plays a critical role in the regulation of transcription. Drosophila GAGA factor directs chromatin remodeling to its binding sites. We show here that Drosophila FACT (facilitates chromatin transcription), a heterodimer of dSPT16 and dSSRP1, is associated with GAGA factor through its dSSRP1 subunit, binds to a nucleosome, and facilitates GAGA factor-directed chromatin remodeling. Moreover,...

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Source

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Identifiers

PMID: 12815073
DOI: 10.1101/gad.1086803
PMCID: PMC196133

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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