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Article

Inter-conversion of neuregulin2 full and partial agonists for ErbB4.

Biochemical and biophysical research communications - 14 Dec 2007

Wilson Kristy J, Mill Christopher P, Cameron Elizabeth M, Hobbs Stuart S, Hammer Robert P, Riese David J

Abstract excerpt

The EGF family hormone NRG2beta potently stimulates ErbB4 tyrosine phosphorylation and coupling to IL3 independence. In contrast, the NRG2alpha splicing isoform has lower affinity for ErbB4, does not potently stimulate ErbB4 phosphorylation, and fails to stimulate ErbB4 coupling. Here we investigate these differences. The NRG2beta Q43L mutant potently stimulates ErbB4 phosphorylation but not ErbB4 coupling to IL3...

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Source

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Identifiers

PMID: 17945187
DOI: 10.1016/j.bbrc.2007.10.004
PMCID: PMC2094732

Genes

EGF
NRG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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