Growth Factor-specific Signaling Pathway Stimulation and Gene Expression Mediated by ErbB Receptors

Abstract excerpt

The mechanisms by which receptor tyrosine kinases (RTKs) utilize intracellular signaling pathways to direct gene expression and cellular response remain unclear. A current question is whether different RTKs within a single cell target similar or different sets of genes. In this study we have used the ErbB receptor network to explore the relationship between RTK activation and gene expression. We profiled growth...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to 14-3-3 protein interactions
• Share to Cytokine Signaling Pathways and Interactions
• Share to HER2/EGFR in Cancer Research