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Article

The immunoglobulin‐like domain of neuregulins potentiates ErbB3/HER3 activation and cellular proliferation

23 Apr 2018

Abstract excerpt

The neuregulins (NRGs) represent a large family of membrane‐anchored growth factors, whose deregulation may contribute to the pathogenesis of several tumors. In fact, targeting of NRG‐activated pathways has demonstrated clinical benefit. To improve the efficacy of anti‐NRG therapies, it is essential to gain insights into the regions of NRGs that favor their pro‐oncogenic properties. Here, we have addressed the...

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PMID: 29683256
DOI: 10.1002/1878-0261.12310

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