Article
Genetic instability syndromes with progeroid features.
Zeitschrift fur Gerontologie und Geriatrie - 1 Oct 2007
Neveling K, Bechtold A, Hoehn H
Abstract excerpt
We discuss examples of the rare human genetic instability syndromes as they present themselves at the chromosome, telomere, and nuclear envelope level. Destabilization of the nuclear envelope due to mutations in the Lamin A/C gene lead to global impairments of the chromatin structure and gene expression with the fatal consequences observed in the Hutchinson-Gilford juvenile progeria syndrome. Patients with...
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