Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Multiple PKCdelta tyrosine residues are required for PKCdelta-dependent activation of involucrin expression--a key role of PKCdelta-Y311.

The Journal of investigative dermatology - 1 Apr 2008

Zhu Ling, Brodie Chaya, Balasubramanian Sivaprakasam, Eckert Richard L

Abstract excerpt

Protein kinase C-delta (PKCdelta) is a key regulator of human involucrin (hINV) gene expression and is regulated by tyrosine phosphorylation. However, a comprehensive analysis of the requirement for individual PKCdelta tyrosine residues is lacking. We show that multiple tyrosine residues influence the ability of PKCdelta to increase hINV gene expression. Mutation of individual PKCdelta tyrosine residues 52, 64,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Substitution
Share to Gene Expression Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Keratinocytes

Share to Phosphorylation

Share to Protein Kinase C-delta

Share to Protein Precursors

Share to Protein Structure, Tertiary

Share to Tyrosine

Source

Open in PubMed Open full text

Identifiers

PMID: 17943181
DOI: 10.1038/sj.jid.5701103
PMCID: PMC3124846

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Multiple PKCdelta tyrosine residues are required for PKCdelta-dependent activation of involucrin expression--a key role of PKCdelta-Y311.PMID 17943181Read ↗

Independence of protein kinase C-delta activity from activation loop phosphorylation: structural basis and altered functions in cells.Semantic proximity Read ↗

The many hats of protein kinase Cδ: one enzyme with many functions.Semantic proximity Read ↗

The human involucrin gene contains spatially distinct regulatory elements that regulate expression during early versus late epidermal differentiation.Semantic proximity Read ↗

Phosphorylation of human polyomavirus BK agnoprotein at Ser-11 is mediated by PKC and has an important regulative functionSemantic proximity Read ↗

CK1δ kinase activity is modulated by protein kinase C α (PKCα)-mediated site-specific phosphorylation.Semantic proximity Read ↗

Threonine 454 phosphorylation in Grainyhead-like 3 is important for its function and regulation by the p38 MAPK pathway.Semantic proximity Read ↗

The distal and proximal regulatory regions of the involucrin gene promoter have distinct functions and are required for in vivo involucrin expression.Semantic proximity Read ↗

Protein kinase C (PKC) delta suppresses keratinocyte proliferation by increasing p21(Cip1) level by a KLF4 transcription factor-dependent mechanism.Semantic proximity Read ↗

Requirements of protein kinase cdelta for catalytic function. Role of glutamic acid 500 and autophosphorylation on serine 643.Semantic proximity Read ↗

The last five amino acid residues at the C-terminus of PRK1/PKN is essential for full lipid responsiveness.Semantic proximity Read ↗

Regulated interaction of protein kinase Cdelta with the heterogeneous nuclear ribonucleoprotein K protein.Semantic proximity Read ↗

Src family kinases phosphorylate protein kinase C delta on tyrosine residues and modify the neoplastic phenotype of skin keratinocytes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.