Article
Silent (synonymous) SNPs: should we care about them?
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2009
Hunt Ryan, Sauna Zuben E, Ambudkar Suresh V, Gottesman Michael M, Kimchi-Sarfaty Chava
Abstract excerpt
One of the surprising findings of the Human Genome Project was that single nucleotide polymorphisms (SNPs), which, by definition, have a minor allele frequency greater than 1%, occur at higher rates than previously suspected. When occurring in the gene coding regions, SNPs can be synonymous (i.e., not causing a change in the amino acid) or nonsynonymous (when the amino acid is altered). It has long been assumed...
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