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Article

The multiple myeloma associated MMSET gene contributes to cellular adhesion, clonogenic growth, and tumorigenicity.

Blood - 15 Jan 2008

Lauring Josh, Abukhdeir Abde M, Konishi Hiroyuki, Garay Joseph P, Gustin John P, Wang Qiuju, Arceci Robert J, Matsui William, Park Ben Ho

Abstract excerpt

Multiple myeloma (MM) is an incurable hematologic malignancy characterized by recurrent chromosomal translocations. Patients with t(4;14)(p16;q32) are the worst prognostic subgroup in MM, although the basis for this poor prognosis is unknown. The t(4;14) is unusual in that it involves 2 potential target genes: fibroblast growth factor receptor 3 (FGFR3) and multiple myeloma SET domain (MMSET). MMSET is...

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Share to Chromosomes, Human, Pair 14
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Colony-Forming Units Assay

Share to Histone-Lysine N-Methyltransferase

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Source

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Identifiers

PMID: 17942756
DOI: 10.1182/blood-2007-05-088674
PMCID: PMC2200833

Genes

FGFR3
SET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The multiple myeloma associated MMSET gene contributes to cellular adhesion, clonogenic growth, and tumorigenicity.PMID 17942756Read ↗

MMSET deregulation affects cell cycle progression and adhesion regulons in t(4;14) myeloma plasma cellsSemantic proximity Read ↗

MMSET is the key molecular target in t(4;14) myelomaSemantic proximity Read ↗

The t(4;14) Translocation in Myeloma Dysregulates Both FGFR3and a Novel Gene, MMSET, Resulting in IgH/MMSET Hybrid TranscriptsSemantic proximity Read ↗

The t(4;14) translocation and FGFR3 overexpression in multiple myeloma: prognostic implications and current clinical strategiesSemantic proximity Read ↗

Overexpression of transcripts originating from the MMSET locus characterizes all t(4;14)(p16;q32)-positive multiple myeloma patientsSemantic proximity Read ↗

Decreased Expression of FAT4 Promotes Multiple Myeloma Proliferation and Migration by Targeting the Hippo/YAP Pathway.Semantic proximity Read ↗

A molecular study of the t(4;14) in multiple myeloma.Semantic proximity Read ↗

The Histone Methyltransferase and Putative Oncoprotein MMSET Is Overexpressed in a Large Variety of Human TumorsSemantic proximity Read ↗

In multiple myeloma, t(4;14)(p16;q32) is an adverse prognostic factor irrespective of FGFR3 expressionSemantic proximity Read ↗

The enigma of ectopic expression of FGFR3 in multiple myeloma: a critical initiating event or just a target for mutational activation during tumor progression.Semantic proximity Read ↗

Mutation, SNP, and isoform analysis of fibroblast growth factor receptor 3 (FGFR3) in 150 newly diagnosed multiple myeloma patientsSemantic proximity Read ↗

REIIBP promotes TLR7-BTK-IL6 pro-inflammatory response through histone H3 lysine methylation in t(4;14) myelomagenesisSemantic proximity Read ↗

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