Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A molecular study of the t(4;14) in multiple myeloma.

British journal of haematology - 1 Aug 2002

Sibley Kathryn, Fenton James A L, Dring Ann M, Ashcroft Andrew J, Rawstron Andrew C, Morgan Gareth J

Abstract excerpt

The t(4;14) translocation is found in approximately 10% of myeloma patients and results in the deregulation of at least two genes, MMSET and fibroblast growth factor receptor 3 (FGFR3), with the formation of a fusion product between MMSET and the immunoglobulin heavy chain (IgH) locus and overexp...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomes, Human, Pair 14
Share to Chromosomes, Human, Pair 4
Share to High Mobility Group Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histone-Lysine N-Methyltransferase

Share to Multiple Myeloma

Share to Receptor, Fibroblast Growth Factor, Type 3

Share to Receptors, Fibroblast Growth Factor

Share to Translocation, Genetic

Source

Identifiers

PMID: 12139740
DOI: 10.1046/j.1365-2141.2002.03618.x

Genes

FGFR3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12139740-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A molecular study of the t(4;14) in multiple myeloma.PMID 12139740Read ↗

Mutation, SNP, and isoform analysis of fibroblast growth factor receptor 3 (FGFR3) in 150 newly diagnosed multiple myeloma patientsSemantic proximity Read ↗

The t(4;14) Translocation in Myeloma Dysregulates Both FGFR3and a Novel Gene, MMSET, Resulting in IgH/MMSET Hybrid TranscriptsSemantic proximity Read ↗

The t(4;14) translocation and FGFR3 overexpression in multiple myeloma: prognostic implications and current clinical strategiesSemantic proximity Read ↗

MMSET deregulation affects cell cycle progression and adhesion regulons in t(4;14) myeloma plasma cellsSemantic proximity Read ↗

Genomic abnormalities in monoclonal gammopathy of undetermined significanceSemantic proximity Read ↗

The multiple myeloma associated MMSET gene contributes to cellular adhesion, clonogenic growth, and tumorigenicity.Semantic proximity Read ↗

In multiple myeloma, t(4;14)(p16;q32) is an adverse prognostic factor irrespective of FGFR3 expressionSemantic proximity Read ↗

A Novel Chromosomal Translocation t(4; 14)(p16.3; q32) in Multiple Myeloma Involves the Fibroblast Growth-Factor Receptor 3 GeneSemantic proximity Read ↗

Novel mutation and RNA splice variant of fibroblast growth factor receptor 3 in multiple myeloma patients at diagnosis.Semantic proximity Read ↗

Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3.Semantic proximity Read ↗

A novel mutation involving the carboxy terminal region of the FGFR3 gene in a multiple myeloma patient with t(4;14).Semantic proximity Read ↗

MMSET is the key molecular target in t(4;14) myelomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.