Mutation, SNP, and isoform analysis of fibroblast growth factor receptor 3 (FGFR3) in 150 newly diagnosed multiple myeloma patients

Abstract excerpt

The t(4;14) translocation in multiple myeloma (MM) is identified in ∼15% of patient samples, dysregulating FGFR3 and MMSET. Activating FGFR3 mutations are observed in myeloma cell lines and in late stage MM but the incidence of mutation in newly diagnosed patient samples is unknown. Gene expression profiling of 150 newly diagnosed patients revealed FGFR3 over-expression in 24 (16%). RT-PCR and FISH confirmed that...

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