Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Decreased Expression of FAT4 Promotes Multiple Myeloma Proliferation and Migration by Targeting the Hippo/YAP Pathway.

Cancer science - 1 Jul 2026

Zhang Lina, Shen Na, Cheng Xin, Shi Qinglin, Chen Lijuan, Shen Xuxing

Abstract excerpt

FAT4 is a member of the protocadherin family and plays an important role in various types of tumors. Multiple myeloma (MM) is a common hematological malignancy. Whole-exome sequencing revealed that FAT4 is a frequently mutated driver gene of MM, but its biological function in MM remains elusive. We performed targeted gene sequencing on MM cells isolated from 161 patients and retrospectively analyzed the clinical...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to Cadherins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Movement

Share to Hippo Signaling Pathway

Share to Multiple Myeloma

Share to Tumor Suppressor Proteins

Share to YAP-Signaling Proteins

Share to Zebrafish

Source

Open in PubMed Open full text

Identifiers

PMID: 42023818
DOI: 10.1111/cas.70404
PMCID: PMC13327098

Genes

FAT4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Decreased Expression of FAT4 Promotes Multiple Myeloma Proliferation and Migration by Targeting the Hippo/YAP Pathway.PMID 42023818Read ↗

Multiple myeloma is affected by multiple and heterogeneous somatic mutations in adhesion- and receptor tyrosine kinase signaling moleculesSemantic proximity Read ↗

Interpreting the molecular biology and clinical behavior of multiple myeloma in the context of global gene expression profilingSemantic proximity Read ↗

IRF4 in multiple myeloma—Biology, disease and therapeutic targetSemantic proximity Read ↗

Single-cell sequencing analysis of multiple myeloma heterogeneity and identification of new theranostic targetsSemantic proximity Read ↗

Identification of evolutionary mechanisms of myelomatous effusion by single-cell RNA sequencingSemantic proximity Read ↗

The multiple myeloma associated MMSET gene contributes to cellular adhesion, clonogenic growth, and tumorigenicity.Semantic proximity Read ↗

Extramedullary myeloma is genomically complex and characterized by near-universal MAPK pathway alterations.Semantic proximity Read ↗

Predictive potential of cuproptosis-related genes in multiple myeloma: Comprehensive analysis based on bone marrow whole-genome sequencingSemantic proximity Read ↗

Characterization of complete lncRNAs transcriptome reveals the functional and clinical impact of lncRNAs in multiple myelomaSemantic proximity Read ↗

Genetic determinants of multiple myeloma risk within the Wnt/beta-catenin signaling pathway.Semantic proximity Read ↗

LncRNA MALAT1 silencing represses CXCL12-induced proliferation, invasion, and homing behavior in multiple myeloma by inhibiting CXCR4Semantic proximity Read ↗

Aberrant lncRNA Expression in Multiple MyelomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.