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Article

Sequence variation and linkage disequilibrium in the GABA transporter-1 gene (SLC6A1) in five populations: implications for pharmacogenetic research.

BMC genetics - 17 Oct 2007

Hirunsatit Rungnapa, Ilomäki Risto, Malison Robert, Räsänen Pirkko, Ilomäki Essi, Kranzler Henry R, Kosten Thomas, Sughondhabirom Atapol, Thavichachart Nuntika, Tangwongchai Sookjaroen, Listman Jennifer, Mutirangura Apiwat, Gelernter Joel, Lappalainen Jaakko

Abstract excerpt

BACKGROUND: GABA transporter-1 (GAT-1; genetic locus SLC6A1) is emerging as a novel target for treatment of neuropsychiatric disorders. To understand how population differences might influence strategies for pharmacogenetic studies, we identified patterns of genetic variation and linkage disequilibrium (LD) in SLC6A1 in five populations representing three continental groups. RESULTS: We resequenced 12.4 kb of...

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Identifiers

PMID: 17941974
DOI: 10.1186/1471-2156-8-71
PMCID: PMC2175509

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