Article
Combining association tests across multiple genetic markers in case-control studies.
Human heredity - 1 Jan 2008
Zhou Huanyu, Wei Lee-Jen, Xu Xiping, Xu Xin
Abstract excerpt
In the search to detect genetic associations between complex traits and DNA variants, a practice is to select a subset of Single Nucleotide Polymorphisms (tag SNPs) in a gene or chromosomal region of interest. This allows study of untyped polymorphisms in this region through the phenomenon of linkage disequilibrium (LD). However, it is crucial in the analysis to utilize such multiple SNP markers efficiently. In...
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