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A genetic association test through combining two independent tests.

Genomics - 1 Sept 2019

Chen Zhongxue, Liu Qingzhong, Wang Kai

Abstract excerpt

Gene- and pathway-based variant association tests are important tools in finding genetic variants that are associated with phenotypes of interest. Although some methods have been proposed in the literature, powerful and robust statistical tests are still desirable in this area. In this study, we propose a statistical test based on decomposing the genotype data into orthogonal parts from which powerful and robust...

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PMID: 30009923
DOI: 10.1016/j.ygeno.2018.07.010

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