Article
An efficient family-based association test using multiple markers.
Genetic epidemiology - 1 Nov 2006
Xu Xin, Rakovski Cyril, Xu Xiping, Laird Nan
Abstract excerpt
In genetic association studies, multiple markers are usually employed to cover a genomic region of interest for localizing a trait locus. In this report, we propose a novel multi-marker family-based association test (T(LC)) that linearly combines the single-marker test statistics using data-driven weights. We examine the type-I error rate in a numerical study and compare its power to identify a common trait locus...
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