Article
A powerful method for combining P-values in genomic studies.
Genetic epidemiology - 1 Dec 2013
Chen Huann-Sheng, Pfeiffer Ruth M, Zhang Shunpu
Abstract excerpt
After genetic regions have been identified in genomewide association studies (GWAS), investigators often follow up with more targeted investigations of specific regions. These investigations typically are based on single nucleotide polymorphisms (SNPs) with dense coverage of a region. Methods are thus needed to test the hypothesis of any association in given genetic regions. Several approaches for combining...
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