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Article

Hepatocyte proliferation during liver regeneration is impaired in mice with liver-specific IGF-1R knockout.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Apr 2006

Desbois-Mouthon Christèle, Wendum Dominique, Cadoret Axelle, Rey Colette, Leneuve Patricia, Blaise Annick, Housset Chantal, Tronche François, Le Bouc Yves, Holzenberger Martin

Abstract excerpt

Recent evidence indicates that growth hormone (GH) is involved in liver regeneration. To test whether insulin-like growth factor I (IGF-I) mediates this effect, we studied liver regeneration induced by partial hepatectomy in liver-specific IGF type 1 receptor knockout (LIGFREKO) mice. The absence of IGF-1R caused a significant decrease in hepatocyte proliferation in males (-52%), but not in females, as assessed...

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PMID: 16484330
DOI: 10.1096/fj.05-4704fje

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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