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Article

Thrombin promotes diet-induced obesity through fibrin-driven inflammation.

The Journal of clinical investigation - 1 Aug 2017

Kopec Anna K, Abrahams Sara R, Thornton Sherry, Palumbo Joseph S, Mullins Eric S, Divanovic Senad, Weiler Hartmut, Owens A Phillip, Mackman Nigel, Goss Ashley, van Ryn Joanne, Luyendyk James P, Flick Matthew J

Abstract excerpt

Obesity promotes a chronic inflammatory and hypercoagulable state that drives cardiovascular disease, type 2 diabetes, fatty liver disease, and several cancers. Elevated thrombin activity underlies obesity-linked thromboembolic events, but the mechanistic links between the thrombin/fibrin(ogen) axis and obesity-associated pathologies are incompletely understood. In this work, immunohistochemical studies...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28737512
DOI: 10.1172/JCI92744
PMCID: PMC5531415

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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