Article
Genetic susceptibility, smoking, obesity and risk of venous thromboembolism.
British journal of haematology - 1 Apr 2010
Severinsen Marianne T, Overvad Kim, Johnsen Søren P, Dethlefsen Claus, Madsen Poul H, Tjønneland Anne, Kristensen Søren R
Abstract excerpt
The F5 G1691A (Factor V Leiden) and F2 G20210A (prothrombin) mutations are linked to an increase in the incidence rate of venous thromboembolism (VTE), but their effects are highly variable. We investigated whether the effects of smoking and obesity might explain this variability. In a case-cohor...
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