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Autocrine/paracrine TGFβ1 is required for the development of epidermal Langerhans cells

15 Oct 2007

Abstract excerpt

Langerhans cells (LCs) are bone marrow (BM)-derived epidermal dendritic cells (DCs) that develop from precursors found in the dermis. Epidermal LCs are absent in transforming growth factor (TGF) beta1-deficient mice. It is not clear whether TGFbeta1 acts directly on LC precursors to promote maturation or whether it acts on accessory cells, which in turn affect LC precursors. In addition, the physiologic source of...

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PMID: 17938236
DOI: 10.1084/jem.20071401

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