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Article

Langerhans cells are not required for graft-versus-host disease

14 Oct 2010

Abstract excerpt

Graft-versus-host disease (GVHD) is initiated and maintained by antigen-presenting cells (APCs) that prime alloreactive donor T cells. APCs are therefore attractive targets for GVHD prevention and treatment. APCs are diverse in phenotype and function, making understanding how APC subsets contribute to GVHD necessary for the development of APC-targeted therapies. Langerhans cells (LCs) have been shown to be...

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Identifiers

PMID: 20944073
DOI: 10.1182/blood-2010-07-299073

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