Article
A role for endogenous transforming growth factor beta 1 in Langerhans cell biology: the skin of transforming growth factor beta 1 null mice is devoid of epidermal Langerhans cells.
The Journal of experimental medicine - 1 Dec 1996
Borkowski T A, Letterio J J, Farr A G, Udey M C
Abstract excerpt
Transforming growth factor beta 1 (TGF-beta 1) regulates leukocytes and epithelial cells. To determine whether the pleiotropic effects of TGF-beta 1, a cytokine that is produced by both keratinocytes and Langerhans cells (LC), extend to epidermal leukocytes, we characterized LC (the epidermal con...
Topics
- Animals
- Cells, Cultured
- Coculture Techniques
- Female
- Flow Cytometry
- Immunosuppressive Agents
- Langerhans Cells
- Lymph Nodes
- Mice
- Mice, Inbred BALB C
- Mice, Knockout
- Phenotype
- Polyenes
- Sirolimus
- Skin
- T-Lymphocytes
- Transforming Growth Factor beta