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Article

In vivo transformation of mouse conventional CD8α+ dendritic cells leads to progressive multisystem histiocytosis

20 Nov 2007

Abstract excerpt

Division and proliferation of dendritic cells (DCs) have been proposed to contribute to homeostasis and to prolonged antigen presentation. Whether abnormal proliferation of dendritic cells causes Langerhans cell histiocytosis (LCH) is a highly debated topic. Transgenic expression of simian virus 40 (SV40) T antigens in mature DCs allowed their transformation in vivo while maintaining their phenotype, function,...

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PMID: 18029555
DOI: 10.1182/blood-2007-06-097576

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