Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ATF4-dependent oxidative induction of the DNA repair enzyme Ape1 counteracts arsenite cytotoxicity and suppresses arsenite-mediated mutagenesis.

Molecular and cellular biology - 1 Dec 2007

Fung Hua, Liu Pingfang, Demple Bruce

Abstract excerpt

Arsenite is a human carcinogen causing skin, bladder, and lung tumors, but the cellular mechanisms underlying these effects remain unclear. We investigated expression of the essential base excision DNA repair enzyme apurinic endonuclease 1 (Ape1) in response to sodium arsenite. In mouse 10T(1/2) fibroblasts, Ape1 induction in response to arsenite occurred about equally at the mRNA, protein, and enzyme activity...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Activating Transcription Factor 4
Share to Arsenites

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Death

Share to DNA-(Apurinic or Apyrimidinic Site) Lyase

Share to Enzyme Induction

Share to NIH 3T3 Cells

Share to Proto-Oncogene Proteins c-jun

Share to Response Elements

Source

Open in PubMed Open full text

Identifiers

PMID: 17938202
DOI: 10.1128/MCB.00974-07
PMCID: PMC2169401

Genes

ATF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ATF4-dependent oxidative induction of the DNA repair enzyme Ape1 counteracts arsenite cytotoxicity and suppresses arsenite-mediated mutagenesis.PMID 17938202Read ↗

Endoplasmic reticulum stress responses and epigenetic alterations in arsenic carcinogenesisSemantic proximity Read ↗

Transactivation of AP-1 in AP-1-luciferase reporter transgenic mice by arsenite and arsenate.Semantic proximity Read ↗

Arsenite exposure inhibits histone acetyltransferase p300 for attenuating H3K27ac at enhancers in low-dose exposed mouse embryonic fibroblast cellsSemantic proximity Read ↗

Continuous activation of Nrf2 and its target antioxidant enzymes leads to arsenite-induced malignant transformation of human bronchial epithelial cells.Semantic proximity Read ↗

N6-methyladenosine mediates the cellular proliferation and apoptosis via microRNAs in arsenite-transformed cells.Semantic proximity Read ↗

The DNA base excision repair protein Ape1/Ref-1 as a therapeutic and chemopreventive targetSemantic proximity Read ↗

Short dysfunctional telomeres impair the repair of arsenite‐induced oxidative damage in mouse cellsSemantic proximity Read ↗

Arsenic-induced apoptosis in the p53-proficient and p53-deficient cells through differential modulation of NFkB pathway.Semantic proximity Read ↗

Poly(ADP-Ribose) Polymerase-1 Inhibition by Arsenite Promotes the Survival of Cells With Unrepaired DNA Lesions Induced by UV ExposureSemantic proximity Read ↗

Oxidative Stress Contributes to Arsenic-induced Telomere Attrition, Chromosome Instability, and ApoptosisSemantic proximity Read ↗

TRIB3 increases cell resistance to arsenite toxicity by limiting the expression of the glutathione-degrading enzyme CHAC1.Semantic proximity Read ↗

Impact of arsenite and its methylated metabolites on PARP-1 activity, PARP-1 gene expression and poly(ADP-ribosyl)ation in cultured human cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.