Article
Transactivation of AP-1 in AP-1-luciferase reporter transgenic mice by arsenite and arsenate.
Anticancer research - 1 Jan 2000
Huang C, Bode A M, Chen N Y, Ma W Y, Li J, Nomura M, Dong Z
Abstract excerpt
Arsenic is a recognized carcinogen, which acts as a tumor promoter rather than as an initiator. Signal transduction pathways leading to activation of AP-1 and mitogen-activated protein kinases are proposed to be responsible for the tumor promotion activity by arsenic. Induction of AP-1 DNA binding activity and c-jun and c-fos expression was reported to be only observed in cells responding to arsenite, but not to...
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