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Poly(ADP-Ribose) Polymerase-1 Inhibition by Arsenite Promotes the Survival of Cells With Unrepaired DNA Lesions Induced by UV Exposure

2 Mar 2012

Abstract excerpt

Human arsenic exposure is associated with increased risk of skin cancer, and arsenite greatly enhances ultraviolet (UV)-induced skin tumors in a mouse model of carcinogenesis. Inhibition of DNA repair is one proposed mechanism for the observed cocarcinogenicity. We have previously demonstrated that low concentrations of arsenite inhibit poly(ADP-ribose) polymerase (PARP)-1, thus interfering with DNA repair...

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PMID: 22387748
DOI: 10.1093/toxsci/kfs099

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