Article
In vivo characterization of human APOA5 haplotypes.
Genomics - 1 Dec 2007
Ahituv Nadav, Akiyama Jennifer, Chapman-Helleboid Audrey, Fruchart Jamila, Pennacchio Len A
Abstract excerpt
Increased plasma triglyceride concentrations are an independent risk factor for cardiovascular disease. Numerous studies support a reproducible genetic association between two minor haplotypes in the human apolipoprotein A5 gene (APOA5) and increased plasma triglyceride concentrations. We thus sought to investigate the effects of these minor haplotypes (APOA5*2 and APOA5*3) on ApoAV plasma levels through the...
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