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Article

Relative contribution of variation within the APOC3/A4/A5 gene cluster in determining plasma triglycerides.

Human molecular genetics - 15 Nov 2002

Talmud Philippa J, Hawe Emma, Martin Steve, Olivier Michael, Miller George J, Rubin Edward M, Pennacchio Len A, Humphries Steve E

Abstract excerpt

Since triglycerides (TG) are a major independent risk factor for coronary heart disease, understanding their genetic and environmental determinants is of major importance. Mouse models indicate an inverse relationship between levels of the newly identified apolipoprotein AV (APOAV) and TG concentrations. We have examined the relative influence of human APOA5 variants on plasma lipids, compared to the impact of...

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Source

Identifiers

PMID: 12417525
DOI: 10.1093/hmg/11.24.3039

Genes

APOA4
APOA5
APOC3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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