Article
An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing.
Science (New York, N.Y.) - 5 Oct 2001
Pennacchio L A, Olivier M, Hubacek J A, Cohen J C, Cox D R, Fruchart J C, Krauss R M, Rubin E M
Abstract excerpt
Comparison of genomic DNA sequences from human and mouse revealed a new apolipoprotein (APO) gene (APOAV) located proximal to the well-characterized APOAI/CIII/AIV gene cluster on human 11q23. Mice expressing a human APOAV transgene showed a decrease in plasma triglyceride concentrations to one-third of those in control mice; conversely, knockout mice lacking Apoav had four times as much plasma triglycerides as...
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