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Article

Gene transfer of apolipoprotein A-V improves the hypertriglyceridemic phenotype of apoa5 (-/-) mice.

Arteriosclerosis, thrombosis, and vascular biology - 1 Mar 2013

Sharma Vineeta, Beckstead Jennifer A, Simonsen Jens B, Nelbach Lisa, Watson Gordon, Forte Trudy M, Ryan Robert O

Abstract excerpt

OBJECTIVE: Apolipoprotein (apo) A-V is a low abundance protein with a profound influence on plasma triacylglycerol levels. In human populations, single nucleotide polymorphisms and mutations in APOA5 positively correlate with hypertriglyceridemia. As an approach to preventing the deleterious effects of chronic hypertriglyceridemia, apoA-V gene therapy has been pursued. METHODS AND RESULTS: Recombinant...

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Source

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Identifiers

PMID: 23329134
DOI: 10.1161/ATVBAHA.112.301078
PMCID: PMC3658105

Genes

APOA5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Gene transfer of apolipoprotein A-V improves the hypertriglyceridemic phenotype of apoa5 (-/-) mice.PMID 23329134Read ↗

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