Article
Marked decrease of LSD-induced stimulus control in serotonin transporter knockout mice.
Pharmacology, biochemistry, and behavior - 1 Jan 2008
Krall C M, Richards J B, Rabin R A, Winter J C
Abstract excerpt
RATIONALE: Based upon extensive studies in the rat, it has been suggested that stimulus control by LSD is mediated by 5-HT2A receptors, with serotonergic receptors of the 5-HT1A and 5-HT2C subtypes playing modulatory roles. In genetically modified mice lacking the serotonin transporter (SERT), 5-HT2A receptor density is decreased and, at a functional level, the head-twitch response following the administration of...
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