Article
Association study of protease activated receptor 1 gene polymorphisms and adverse pregnancy outcomes: results of a pilot study in Israel.
American journal of medical genetics. Part A - 1 Nov 2007
Grisaru-Granovsky Sorina, Tevet Aharon, Bar-Shavit Rachel, Salah Zaidoun, Elstein Deborah, Samueloff Arnon, Altarescu Gheona
Abstract excerpt
Protease activated receptor 1 (PAR1), the thrombin receptor, is implicated in hemostasis, tissue remodeling, and is critical in early placentation. PAR1 polymorphisms that influence coagulation and adhesion molecule expression may compromise formation of a normal placenta, thereby resulting in adverse outcomes. This study is a prospective, case-control comparison of Israeli mother-neonate (singletons) pairs of...
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