Article
Candidate-gene association study of mothers with pre-eclampsia, and their infants, analyzing 775 SNPs in 190 genes.
Human heredity - 1 Jan 2007
Goddard Katrina A B, Tromp Gerard, Romero Roberto, Olson Jane M, Lu Qing, Xu Zhiying, Parimi Neeta, Nien Jyh Kae, Gomez Ricardo, Behnke Ernesto, Solari Margarita, Espinoza Jimmy, Santolaya Joaquin, Chaiworapongsa Tinnakorn, Lenk Guy M, Volkenant Kimberly, Anant Madan Kumar, Salisbury Benjamin A, Carr Janet, Lee Min Soeb, Vovis Gerald F, Kuivaniemi Helena
Abstract excerpt
Pre-eclampsia (PE) affects 5-7% of pregnancies in the US, and is a leading cause of maternal death and perinatal morbidity and mortality worldwide. To identify genes with a role in PE, we conducted a large-scale association study evaluating 775 SNPs in 190 candidate genes selected for a potential role in obstetrical complications. SNP discovery was performed by DNA sequencing, and genotyping was carried out in a...
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