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Article

Association of ACE2 Gene Variants with Adverse Perinatal Outcomes in COVID-19 Infected Pregnant Women in Kazakhstan.

Viruses - 30 Oct 2024

Mukhtarova Kymbat, Tazhibayeva Karina, Myrzabekova Aigul, Koikov Vitaliy, Khamidullina Zaituna, Terzic Milan, Bapayeva Gauri, Zhumambayeva Saule, Azizan Azliyati, Sarría-Santamera Antonio

Abstract excerpt

SARS-CoV-2 utilizes the angiotensin-converting enzyme 2 (ACE2) receptors located on membranes to enter host cells. Nevertheless, the ACE2 gene primarily encodes for a zinc metalloproteinase, which is a part of the renin-angiotensin system (RAS). ACE2 downregulation results in the deregulation of RAS in favor of pro-fibrosis, pro-apoptosis, oxidative stress, pro-inflammation, aldosterone production and release,...

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Identifiers

PMID: 39599812
DOI: 10.3390/v16111696
PMCID: PMC11598833

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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