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Article

Protective effect of a thrombin receptor (protease-activated receptor 1) gene polymorphism toward venous thromboembolism.

Arteriosclerosis, thrombosis, and vascular biology - 1 Feb 2000

Arnaud E, Nicaud V, Poirier O, Rendu F, Alhenc-Gelas M, Fiessinger J N, Emmerich J, Aiach M

Abstract excerpt

The human protease-activated receptor 1 (PAR-1) is activated by thrombin at the surface of platelets and endothelial cells, 2 cells that are implicated in hemostasis and thrombosis. We studied the PAR-1 gene in a large case-control study from the Paris Thrombosis Study (PATHROS), and the possible implication of polymorphisms in venous thromboembolism was evaluated. Two polymorphisms were found in the 5'...

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PMID: 10669659
DOI: 10.1161/01.atv.20.2.585

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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