Article
Nonrandom distribution of hepatitis C virus quasispecies in plasma and peripheral blood mononuclear cell subsets.
Journal of virology - 1 Nov 1999
Roque Afonso A M, Jiang J, Penin F, Tareau C, Samuel D, Petit M A, Bismuth H, Dussaix E, Féray C
Abstract excerpt
The existence of an extrahepatic reservoir of hepatitis C virus (HCV) is suggested by differences in quasispecies composition between the liver, peripheral blood mononuclear cells, and serum. We studied HCV RNA compartmentalization in the plasma of nine patients, in CD19(+), CD8(+), and CD4(+) positively selected cells, and also in the negatively selected cell fraction (NF). HCV RNA was detected in all plasma...
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