[Compartmental distribution of hepatitis C virus quasispecies in mononuclear cells and liver].

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Article

[Compartmental distribution of hepatitis C virus quasispecies in mononuclear cells and liver].

Zhonghua yi xue za zhi - 1 Apr 1998

Jiang J, Zhang L, Gigou M

Abstract excerpt

OBJECTIVE: To explore the role of the infection of monouclear cells by hepatitis C virus(HCV) in the chronicity of HCV infection. METHODS: Direct sequencing of the amplified hypervariable region (HVR) gene of HCV was used to distinguish main HCV quasispecies infecting non-hepatocytes from those infecting hepatocytes and circulating virions. The main HCV quasispecies in peripheral blood mononuclear cells(PBMC),...

Topics

Amino Acid Sequence
Base Sequence
Genetic Variation
Hepacivirus
Hepatitis C, Chronic
Humans
Leukocytes, Mononuclear
Liver
Molecular Sequence Data
Mutation

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PMID: 10923481

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