Article
Toll-like receptor 2 (TLR) -196 to 174del polymorphism in gastro-duodenal diseases in Japanese population.
Digestive diseases and sciences - 1 Apr 2008
Tahara Tomomitsu, Arisawa Tomiyasu, Wang Fangyu, Shibata Tomoyuki, Nakamura Masakatsu, Sakata Mikijyu, Hirata Ichiro, Nakano Hiroshi
Abstract excerpt
Toll-like receptors (TLRs) play important roles in the signaling of many pathogen-related molecules and endogenous proteins associated with immune activation. -196 to -174del polymorphism affects the TLR2 gene and alters its promoter activity. We investigated the influence of TLR2 -196 to -174del polymorphism on the risk of gastro-duodenal diseases, on the severity of Helicobacter pylori-induced gastritis in a...
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