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Article

Toll-like receptor 2 -196 to 174del polymorphism influences the susceptibility of Japanese people to gastric cancer.

Cancer science - 1 Nov 2007

Tahara Tomomitsu, Arisawa Tomiyasu, Wang Fangyu, Shibata Tomoyuki, Nakamura Masakatsu, Sakata Mikijyu, Hirata Ichiro, Nakano Hiroshi

Abstract excerpt

Toll like receptors (TLR) play important roles in the signaling of many pathogen-related molecules and endogenous proteins associated with immune activation. The -196 to -174del polymorphism affects the TLR2 gene and alters its promoter activity. We investigated the influence of the TLR2-196 to -174del polymorphism on the occurrence of non-cardiac gastric cancer (NCGC) in a Japanese population. The study was...

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Identifiers

PMID: 17711514
DOI: 10.1111/j.1349-7006.2007.00590.x
PMCID: PMC11158170

Genes

TLR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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