Article
Antagonistic roles of Wnt5 and the Drl receptor in patterning the Drosophila antennal lobe.
Nature neuroscience - 1 Nov 2007
Yao Ying, Wu Yuping, Yin Chong, Ozawa Rie, Aigaki Toshiro, Wouda Rene R, Noordermeer Jasprina N, Fradkin Lee G, Hing Huey
Abstract excerpt
Numerous studies have shown that ingrowing olfactory axons exert powerful inductive influences on olfactory map development. From an overexpression screen, we have identified wnt5 as a potent organizer of the olfactory map in Drosophila melanogaster. Loss of wnt5 resulted in severe derangement of the glomerular pattern, whereas overexpression of wnt5 resulted in the formation of ectopic midline glomeruli. Cell...
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