Article
DWnt4 regulates the dorsoventral specificity of retinal projections in the Drosophila melanogaster visual system.
Nature neuroscience - 1 Jan 2006
Sato Makoto, Umetsu Daiki, Murakami Satoshi, Yasugi Tetsuo, Tabata Tetsuya
Abstract excerpt
In Drosophila melanogaster, the axons of retinal photoreceptor cells extend to the first optic ganglion, the lamina, forming a topographic representation. Here we show that DWnt4, a secreted protein of the Wnt family, is the ventral cue for the lamina. In DWnt4 mutants, ventral retinal axons misprojected to the dorsal lamina. DWnt4 was normally expressed in the ventral half of the developing lamina and DWnt4...
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