Article
Neuroanatomy of fragile X syndrome is associated with aberrant behavior and the fragile X mental retardation protein (FMRP).
Annals of neurology - 1 Jan 2008
Gothelf Doron, Furfaro Joyce A, Hoeft Fumiko, Eckert Mark A, Hall Scott S, O'Hara Ruth, Erba Heather W, Ringel Jessica, Hayashi Kiralee M, Patnaik Swetapadma, Golianu Brenda, Kraemer Helena C, Thompson Paul M, Piven Joseph, Reiss Allan L
Abstract excerpt
OBJECTIVE: To determine how neuroanatomic variation in children and adolescents with fragile X syndrome is linked to reduced levels of the fragile X mental retardation-1 protein and to aberrant cognition and behavior. METHODS: This study included 84 children and adolescents with the fragile X full mutation and 72 typically developing control subjects matched for age and sex. Brain morphology was assessed with...
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