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Article

Topological methods reveal high and low functioning neuro-phenotypes within fragile X syndrome.

Human brain mapping - 1 Sept 2014

Romano David, Nicolau Monica, Quintin Eve-Marie, Mazaika Paul K, Lightbody Amy A, Cody Hazlett Heather, Piven Joseph, Carlsson Gunnar, Reiss Allan L

Abstract excerpt

Fragile X syndrome (FXS), due to mutations of the FMR1 gene, is the most common known inherited cause of developmental disability as well as the most common single-gene risk factor for autism. Our goal was to examine variation in brain structure in FXS with topological data analysis (TDA), and to assess how such variation is associated with measures of IQ and autism-related behaviors. To this end, we analyzed...

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Identifiers

PMID: 24737721
DOI: 10.1002/hbm.22521
PMCID: PMC4113391

Genes

FMR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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